HITMAN's developer IO Interactive split the game into several distinct episodes - each set in a different location - released on a monthly basis. We picked the Marrakesh and Bangkok missions to benchmark the RX 580 and GTX 1060 in 1440p and maxed out settings.
There's not much difference on the Pascal-based GPU between DX11 and DX12 - the NPC heavy Moroccan market performs better on the explicit API, the outside section of the Himmapan Luxury Hotel Resort favors DirectX 11. RX 580 sees a major performance uplift in the Marakesh scene, DX12 is 12% faster than DX11 on that specific level. These results highlight that one can arrive at a very different conclusion benchmarking only a tiny portion of the game, furthermore, single chart results really don't tell the whole story.
HITMAN (2016) results
HITMAN (2016) FPS & FCAT charts
HITMAN (2016) RX 580 DX11 FPS chart
HITMAN (2016) RX 580 DX11 FCAT chart
HITMAN (2016) RX 580 DX12 FPS chart
HITMAN (2016) RX 580 DX12 FCAT chart
HITMAN (2016) GTX 1060 DX11 FPS chart
HITMAN (2016) GTX 1060 DX11 FCAT chart
HITMAN (2016) GTX 1060 DX12 FPS chart
HITMAN (2016) GTX 1060 DX12 FCAT chart